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Endocrinology, Vol 101, 1643-1646, Copyright © 1977 by Endocrine Society

ARTICLES

beta-Endorphin secretion of arginine vasopressin in vivo

RE Weitzman, DA Fisher, S Minick, N Ling and R Guillemin

The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes compared to controls. In contrast beta-endorphin had no significant effect on AVP release from isolated rat neural lobes in vitro. beta-Endorphin stimulates AVP secretion in vivo, but this is not due to a direct action upon the neural lobe.


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