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Endocrinology, Vol 101, 1343-1345, Copyright © 1977 by Endocrine Society

ARTICLES

Dopamine enhances the action of prolactin on rat blood vessels. Implications for dopamine effects on plasma prolactin

MS Manku, DF Horrobin, H Zinner, M Karmazyn, RO Morgan, AI Ally and RA. Karmali

It has been claimed that dopamine enhances peripheral uptake of prolactin. Dopamine at 2.1 x 10(-9)M, a concentration which had no effect by itself, enhanced both the potentiation of rat mesenteric vascular reactivity caused by 50ng/ml ovine prolactin and the inhibition of reactivity caused by 500ng/ml prolactin. These observations are consistent with the proposal that dopamine can interact peripherally with prolactin.




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Copyright © 1977 by The Endocrine Society