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Endocrinology, Vol 100, 1303-1305, Copyright © 1977 by Endocrine Society

ARTICLES

Isoproterenol stimulation of heme synthesis in cultures of human fetal liver from early gestation

LF Congote and S Solomon

The role of isoproterenol in the synthesis of heme associated with hemoglobin has been studied in primary cultures of human fetal liver. This drug (10-10M) stimulated the incorporation of 59Fe into heme associated with hemoglobin in cell cultures of livers obtained from human fetuses 8 to 10 weeks gestation but was inactive in cell cultures prepared from livers of older fetuses. Isoproterenol has its optimal activity at a much earlier time in gestation than that previously reported for testosterone or erythropoietin. The interpretation of these results is that there is present a cell population in human fetal liver early in gestation with the appropriate isoproterenol-receptors and capable of erythroid differentiation after exposure to the drug.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1977 by The Endocrine Society