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*GLUCAGON

Endocrinology, Vol 100, 1284-1286, Copyright © 1977 by Endocrine Society

ARTICLES

Effect of somatostatin on neurotensin-induced glucagon release and hyperglycemia

M Ukai, I Inoue and T Itatsu

Administration of neurotensin to dogs resulted in rises in circulating blood glucose, glucagon and insulin levels, the rise in glucagon being more pronounced than that in insulin. Infusion of somatostatin along with neurotensin suppressed glucagon and insulin responses to neurotensin and prevented the rise in blood glucose levels. These results suggest that the hyperglycemia seen after neurotensin is due to neurotensin stimulation of glucagon release over insulin release.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1977 by The Endocrine Society