Endocrinology, Vol 100, 782-785, Copyright © 1977 by Endocrine Society
An intrarenal effect of somatostatin on water excretion
IA Reid and JC Rose
Department of Physiology, University of California, San Francisco 94143.
Intrarenal infusion of somatostatin in anesthetized dogs produced a prompt
increase in urine flow in association with a decrease in urinary osmolality
and an increase in free water clearance. These changes occurred in the
absence of changes in arterial pressure, renal plasma flow, osmolar
clearance, electrolyte excretion or cyclic AMP excretion. The diuretic
effect occurred primarily in the infused kidney indicating a direct
intrarenal action rather than suppression of vasopressin secretion. This
diuretic action of somatostatin may result from inhibition of the action of
vasopressin on the renal medulla but other possible mechanisms cannot be
excluded.
